CardioSim
One Platform, Every Scale of the Heart
CARDIOSIM is a web-based research platform for simulating cardiovascular physiology, from ion channels and single cells through to tissues, whole organs, and patient-specific digital twins. There is no software to install.
Multi-scale Simulation
Connect cell, tissue, and organ-level models in one consistent environment, so you can move from a single ion channel to a full virtual heart without changing tools.
CiPA-aligned Cardiac Safety
Run regulatory-aligned drug safety workflows with simulation, bootstrap analysis, biomarker extraction, and AI-assisted risk prediction.
AI & Digital Twin
Combine mechanistic simulation with AI biomarker models and patient-specific digital twins for personalized cardiovascular insight.
Built for researchers, clinicians & students
Whether you are validating a hypothesis, screening a compound, or learning how the heart works, CARDIOSIM gives you a sandbox to try it in first.
7 Modules. One Integrated Platform.
Each module focuses on a different scale or question. Pick one to start with, or combine several across your research workflow.
01Electrophysiology
Cellular & Tissue Electrophysiology
Simulate the electrical activity of excitable cells and tissues — from single neurons to cardiac, smooth and skeletal muscle — to study ion channels and action potentials.
Explore Module
02In Silico Research
Virtual Population Studies
Run large-scale virtual population studies, explore genetic variation, and analyze restitution properties to test hypotheses before moving to the lab.
Explore Module
03CiPA – Cardiac Safety
Drug-Induced Risk Analysis
Assess drug-induced cardiac risk with CiPA-aligned workflows: bootstrap sampling, in silico simulation, biomarker postprocessing, and AI-assisted prediction models.
Explore Module
043D Organ Model
Whole-Organ Simulation
Move from cell to organ with three-dimensional simulations of cardiac electrical propagation and mechanical contraction across the whole heart.
Explore Module
05Toxicity Prediction
Toxicity Evaluation
Predict and interpret cardiotoxicity risk with Tox-CML and Cardiosim-Tox. Tox-CML is available to try instantly — no sign-in required.
Explore Module
06Circulation Model
Hemodynamic Digital Twin
Model systemic circulation and blood pressure response, and build a personalized cardiovascular digital twin from patient-specific data.
Explore Module
07V-Atrial Ablation
Ablation Planning Support
Visualize and plan atrial ablation procedures with simulation-driven support for treatment strategy and outcome prediction.
Explore ModuleExplore CARDIOSIM free. No sign-up required.
Open the platform and run a real cardiac cell simulation in your browser, from the ion currents up to the action potential. Nothing to install and no account to make. The rest of CARDIOSIM is there to look through, and yours to use whenever you are ready.
Explore CARDIOSIMFrom Sign-up to Simulation in 5 Steps
CARDIOSIM runs entirely in your browser. There is nothing to download and nothing to install.
Create an Account
Sign up for free to unlock all 7 simulation modules and save your work.
Choose a Module
Pick the scale that fits your question, from single-cell electrophysiology up to whole-organ models.
Set Up Your Simulation
Configure parameters, select cell types or conditions, and prepare your run. All of it happens in the browser.
Run & Visualize
Execute the simulation and explore results through interactive plots and 3D visualizations.
Analyze & Export
Use built-in AI models to interpret results, then export data or share your setup with collaborators.
New to CARDIOSIM? Try Tox-CML now. No account needed.
Launch Tox-CMLWhy CardioSim?
A cloud-native platform for cardiac electrophysiology simulation, safety assessment, and AI-assisted risk prediction, built for pharma, CROs, and research institutions.
Regulatory-Aligned Modeling
Rapid, reproducible electrophysiology-based CARDIOSIM modeling systematically supports ICH S7B/E14 compliance while reducing dependence on animal testing.
High-Throughput Analysis
High-efficiency parallel simulation maximizes research productivity, with visualized results and automated reporting that speed up interpretation and decisions.
Confident Drug Development
Pharmaceutical companies, CROs, and research institutions use CARDIOSIM to manage cardiac toxicity risk precisely and strengthen regulatory compliance.
Revised ICH S7B/E14 Guideline: Comprehensive in vitro Proarrhythmia Assay (CiPA)
CardioSim v1.0 for in silico Assay
Technical Specifications
- Cloud-based cardiac simulation supporting scalable and collaborative workflows
- ECG generation and cardiac electrophysiology simulation support
- Preclinical cardiac safety assessment for pharmaceuticals and medical devices
- Arrhythmia simulation (atrial fibrillation, ventricular fibrillation, premature contractions/ectopic beats)
- Personalized cardiovascular digital twin construction for model development and optimization
- Large-scale research with CPU/GPU parallel acceleration
- Automated report and visualization generation for rapid result interpretation
- Educational modules for learning physiology and electrophysiology
Key Features & Applications
- Input Data: Multi-ion channel voltage clamp data (INa, INaL, IKr, ICaL)
- Data Fitting: Ion channel kinetics modeling and uncertainty quantification using Hill model and Markov chain model
- Data Bootstrap: Monte Carlo-based bootstrap algorithm
- In silico Simulation: Multi-scale cardiac electrophysiology simulation, from single cell to tissue to whole heart
- AI-based Cardiotoxicity Prediction: Built-in machine learning model predicting arrhythmia and cardiac toxicity risk
Patents & Publications
16 SCI(E) papers related to CardioSim software
- Drug Cardiac Toxicity Assessment Method Using Ordinal Logistic Regression Model with Multiple In Silico Biomarkers (2023.12.08)
- Drug Cardiac Toxicity Assessment Method Based on Potential Signals of Multi-Electrode Arrays (2022.12.12)
- Cardiac Simulation Method and Device Based on Genetic Variants